Sunday night's Steam Packet sailing from Douglas to Heysham (18 November) has been cancelled due to adverse weather conditions.
The scheduled return from Lancashire at 2.15am Monday will therefore not operate either.
The decision's been made ahead of predicted very strong winds in the Irish Sea later tonight.
No decision's yet been made on Monday's Ben-my-Chree sailings.
The company says it will review forecasts and make a final decision on its 8.45 am Isle of Man to Heysham service and the afternoon return, at 7am tomorrow (19 November).
Evidence sought for Area Plan inquiry
Traffic lights in operation by Palatine Health Centre
Disruption at Ronaldsway airport following incident with light aircraft
Hopes for better working relationship between government and hospitality sector
'A lot of work to do' on low income housing
Public servants killed in the line of duty eligible for new award
