Police say as many as eight vehicles were involved in a pile up, just south of Ballaugh Bridge at lunchtime today.
At least one person has serious injuries and was airlifted to hospital.
It's understood motorbikes and cars were involved in the incident.
The stretch of the TT course from Douglas Road Corner, Kirk Michael to Ballaugh Bridge has been closed to traffic since just after midday, and will remain so until 6pm at the earliest.
Looneys of Ramsey to close
Number of factors behind the decision
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Chief Minister says work is ongoing to make the route commercially viable
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Comes after concerns raised about the issues facing the industry
Fine for Douglas man caught with cocaine in car park
20-year-old followed by undercover police
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Ramsey crews called out to vehicle fire on coast roadÂ
Sewerage, population, GP appointments and housing among the west's top issues for CoMin
Residents made full use of Treasury's presence
