Defeat to St. John's will confirm drop
Defeat at home to St. John's will spell relegation from the Canada Life Premier League for Ayre.
It has been a miserable season for the northerners with only a single draw so show from 19 games played - they have also had a points deduction.
Leaders St. George's, fresh from their Railway Cup triumph on Boxing Day, face Ramsey at Glencrutchery Road.
Nine points adrift in second are St. Mary's who entertain third placed Corinthians at The Bowl.
Elsewhere, Colby host Peel, Laxey travel to Douglas Athletic and Union Mills play Rushen.
There's a top-of-the-table clash in Division Two when leaders Douglas Royal go to Castletown.