In Football, Premier League leaders Laxey have the week off so it gives their rivals a chance to catch up.
Second placed St. Mary's can close to within a point if they see off the challenge of fourth in the table Peel at The Bowl.
Champions St. George's face Corinthians.
In Rugby, Douglas, Ramsey and Vagabonds are all in South Lancashire and Cheshire Division Two.
And the Hockey Mixed Premier League opens with Champions Valkyrs "A" facing Vikings "A" at the National Sports Centre at 2.05pm.
Football: Railway Cup hopefuls all maintain pace in premier league
Castletown stay four points clear atop Division 2
Rugby: Vagabonds Ladies stay top with another victory
Vagabonds men and Douglas also take respective wins on home soil
Hockey: Harlequins A beat rivals to close in on prem leaders
Bacchas B take important victory in battle for top-flight safety
FC Isle of Man torn apart at Barnoldswick Town
It's the Manx side's heaviest ever league defeat
