Saints could go nine clear with win
Canada Life Premier League champions St Mary's have the chance to widen their advantage at the top to at least 9 points if they win away at Douglas Royal.
Two of their closest rivals, Peel and St Georges, are without a game this weekend.
Fourth placed Rushen welcome Laxey to Port Erin while fifth in the table Corinthians travel north to face Ramsey.
The other two fixtures in the top flight are Marown against Douglas Athletic and Pulrose make the short trip to Old Boys.
After their cup triumph last Saturday, Division Two leaders Colby have another test when they face promotion rivals Foxdale at Billygoat Park.