Combination Division One Champions Old Boys enter Football's Ascot Hotel Junior Cup on Saturday afternoon.
They had a bye in the preliminary round and make the short trip to Glencrutchery Road to meet St. George's.
Geordies have vastly improved in the second half of the season and could pose a big threat to Old Boys.
There's a close game in prospect at Croit Lowey where Rushen host Ramsey.
Combination Two winners Douglas Athletic get the opportunity to measure themselves against higher opposition when they welcome St. John's.
Elsewhere, Corinthians are at home to Union Mills, Ayre travel to Braddan, Douglas & District look to upset Peel, Marown tackle Douglas Royal and Gymns meet Laxey.