Manchester visit Port-e-Chee
Rugby - Douglas will be aiming to build on their winning start to the new season in South Lancashire and Cheshire Division One.
They beat Liverpool St. Helen's 21-18 away last Saturday and begin their home campaign at Port-e-Chee against Manchester.
Vagabonds lost heavily at home to Winnington Park a week ago and travel to Dukinfield in Division Two.
In Division Three, Ramsey started with a hard-fought victory at Liverpool University and welcome Mossley Hill to the Mooragh Park.
Vagabonds ladies begin their fixtures in Women's NC North One at Ballafletcher against Altrincham Kersal.
Two games in the Shimmin Wilson Manx Shield - Southern Nomads play Noa Nomads and Western Vikings face Emerging Nomads.