Weather permitting, St. George's aim to close in on their 5th Premier League title and 14th top flight honour in all this evening.
They play Old Boys at Glencrutchery Road needing six points from their remaining five games to lift the silverware for the 8th time in the last 10 years.
However, they could be celebrating this evening if they win and Laxey fail to beat Ramsey.
Elsewhere, Marown's relegation to Division Two will be confirmed if they lose at home to Rushen.
The three other sides trying to avoid the one remaining relegation place are all in action.
Gymns are at home to Peel, Castletown go to St. Mary's with the match switched to Ballafletcher and Ramsey will battle for their own cause at Laxey.
In Division Two, Colby need to win at Ayre to keep their promotion hopes boiling and Michael host Onchan.
The other two fixtures see Pulrose entertain Braddan and Foxdale visit Ronaldsway.