FC Isle of Man away in Guernsey
With FC Isle of Man away playing Guernsey, some of the leading sides will have players missing for Saturday afternoon's Canada Life Premier League fixtures.
Leaders Rushen play champions St Mary's at Croit Lowey with both teams having to rely on squad depth.
Second-in-the-table Corinthians will defend their 100% start to the campaign when they visit Marown.
St Georges are at home against Douglas Royal, Douglas Athletic go to Ramsey and St Johns entertain Ayre.
Two teams unused to struggling at the bottom meet at Blackberry Lane with Old Boys up against Peel.