A point for the Saints will seal first top flight crown in 16 years
St Marys could win their first top flight title in 16 years later.
They know at least a point away to Douglas Athletic will be enough to guarantee them the Canada Life Premier League.
The Saints will win it, regardless of their result, if Peel fail to beat defending champions St Georges at home.
This evening's other match sees fourth-placed Corinthians complete their league fixtures against Old Boys at Blackberry Lane.
This will be the first time in nine years that someone other than Geordies will win the title.
Rushen United were the last club to do so, in 2010.