Fourth placed Old Boys travel to second in the table Rushen in the top match in the Canada Life Premier League this afternoon (Saturday).
Unbeaten leaders and champions St George's, four points clear and with games in hand on their main rivals, should gain a further win at home to bottom side Ayre.
Elsewhere, Laxey finish 2011 at home to Castletown, Corinthians host Ramsey, St John's entertain Ramsey Youth Centre and Gymns make the short trip to the Bowl to face St Mary's.
In Division Two, promotion rivals Union Mills and Onchan meet at Garey Moar, and Colby play their last match at Glen Road before moving to a new facility across the Main Road.
Their opponents today are Douglas and District.