Peel tackle Rushen at Douglas Road
The newly refurbished grandstand at Douglas Road will be officially opened this afternoon and named the Terry Vincent stand.
And spectators in the west will be treated to an "Old Firm" battle between Peel and Rushen.
The southern side took the honours on the opening day of the season with a 3-2 win at Croit Lowey.
Leaders Corinthians tackle Douglas Athletic at Ballafletcher.
Champions St. George's welcome St. John's to Glencrutchery Road and St. Mary's travel to Colby.
There's a big clash in Division Two between leaders Pulrose and promotion challengers Ramsey Youth Centre.