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Roads around the Billown Circuit in the south of the Island will close at 6.05pm today (Friday), at the start of the Blackfords Pre-TT Classic meeting.
The first practice session will get under way at 6.15pm and the roads will reopen no later than 9.35pm.
There will be a further practice session tomorrow afternoon, with one race at 4pm.
The rest of the race programme takes place throughout the day on Monday.
Athletics: Big Island turnout expected at Manchester Marathon
It's the second largest event of its type in the UK
Football: Colby stun defending champions in Hospital Cup
Douglas High School Old Boys relegated from premier league during Saturday clashes
Rugby: Douglas beaten in Regional 2 North West play-offs
Ramsey win final home game of their season against Congleton
Spirited FC Isle of Man lose out at Padiham
Both sides finish the game with ten men after entertaining contest
