Leaders Geordies have the weekend off
With Canada Life Premier League leaders St. George's not playing, St. Mary's have the opportunity to move to within two points if they win their game in hand.
They welcome Old Boys to The Bowl in a match which kicks-off at 2.30pm.
All other matches start at two o'clock.
Third in the table Corinthians are at home to Laxey while fellow Railway Cup semi-finalists Peel visit Rushen in the "Old Firm" clash.
Elsewhere, St. John's host Ramsey, Union Mills tackle Douglas Athletic and Colby head north to Ayre.