Ramsey host Douglas in South Lancashire and Cheshire Division Two today (Saturday), the third time Manx sides have met so far this season.
The Mooragh Park outfit will be aiming to climb further away from the bottom of the table, but face a tough task against the league leaders.
Elsewhere, Vagabonds will look to maintain their form with a home win over Ellesmere Port.
Meanwhile, in the Manx Shield Douglas B and Castletown face each other, with the capital side looking for the win which would keep them in the hunt for the title.
Castletown, though bottom, have games in hand and could still finish in the top three if they win their remaining five games.
Vagabonds B host Emerging Nomads, who surprisingly beat Douglas B last weekend.