Blue Islands is to stop its services to Jersey and Guernsey next year.
Flights will end in February.
The company is also stopping its Bournemouth route.
The company says both have seen a decline in numbers, and better travel options are now available via Southampton and London City.
It adds that passengers trevelling from the Isle of Man have daily through options to Jersey or Guernsey via City airport, rather than the thrice-weekly service they have been offering.
Airport Director Ann Reynolds says it's bad news for the Island, but she isn't surprised that the company is pulling out as numbers have been dwindling: