Less than a fortnight after it closed for business, thieves have targeted the Grand Island Hotel in Ramsey.
A number of items were stolen and damage caused sometime between last Thursday night and Friday.
Police don’t yet know how the building was accessed.
Sergeant Darren Hughes says the site poses serious health and safety risks.
Anyone with information is asked to contact police headquarters on 631212 or the anonymous Crimestoppers number – 0800 555 111.