The body of a 54-year-old man was found in Douglas this morning (Saturday), leading to road closures at Hillside Avenue and Wesley Terrace in connection with the incident.
Two men have been arrested and are being detained at Police Headquarters. They will be interviewed in due course.
Officers say the death is being treated as 'suspicious'.
The Coroner of Inquests has been informed and a Home Office pathologist will hold a post-mortem examination tomorrow.
Anybody who saw or heard a disturbance in Wesley Terrace at around 6am today is being urged to ring Police Headquarters on 631212, or Crimestoppers anonymously on 0800 555 111