A visiting motorcyclist from France lost his life in a head-on collision with a Land Rover at about 9.40am today.
It happened on the main road from Ballacraine to Kirk Michael, near the 11th Milestone.
The motorcycle was being ridden in the direction of the TT course. The Land Rover was travelling in the opposite direction and was being driven by a Man from Lezayre.
Nobody in the Land Rover was injured.
The road between Cronk-y-Voddy crossroads and Barregarrow was closed for four hours, while the energency services dealt with the incident.
Police are appealing for witnesses.
Anybody who saw the fatal crash, or either of the vehicles involved, before it happened, is asked to ring the Road Policing Unit at Police Headquarters.
The section of the TT course between Braddan Bride and the Railway Inn at Union Mills was closed to traffic this evening, following a road accident near the entrance to the Snugborough trading estate.
Two vehicles were involved, namely a motorcycle and a car and one person suffered leg injuries.
The road was expected to reopen at about 11.30pm.
Earlier the stretch of the course from Creg-ny-Baa to Hillberry was closed, after a motorcylist came off his machine and suffered a broken femur.
That part of the clourse reopened not long after 7pm.