Rugby's Manx Cup semi-finals take place on Saturday afternoon.
Holders Douglas meet Manx Shield Champions Southern Nomads at Port-e-Chee while Vagabonds entertain Ramsey at Ballafletcher.
The northerners have won both encounters in South Lancashire and Cheshire Division Two this season.
In Football, Old Boys and Peel clash for the third time of asking in the Paddy Power F.A. Cup first round at Blackberry Lane - the match has been postponed twice due to a waterlogged pitch.
In the Canada Life Premier League, leaders St. George's travel down Glencrutchery Road to Tromode to play Gymns.
The sides in third and fourth meet at The Bowl when St. Mary's and Laxey clash and there is a big relegation game between the bottom two sides Marown and Ramsey.
In Hockey, the Men's and Ladies Cup competitions begin.
Men's holders Valkyrs "A" open their defence against Castletown "A" and Ladies holders Vikings "A" start their campaign at home to Bacchas "B".