In Football, Premier League leaders Laxey have the week off so it gives their rivals a chance to catch up.
Second placed St. Mary's can close to within a point if they see off the challenge of fourth in the table Peel at The Bowl.
Champions St. George's face Corinthians.
In Rugby, Douglas, Ramsey and Vagabonds are all in South Lancashire and Cheshire Division Two.
And the Hockey Mixed Premier League opens with Champions Valkyrs "A" facing Vikings "A" at the National Sports Centre at 2.05pm.
FC Isle of Man to host in-form Atherton LR
Visitors currently on eight-match winning streak
Hockey: Cup semi-finals await this weekend
Places in April finals up for grabs in last-four phase
Rugby: Douglas' play-off quest to continue against Firwood Waterloo
Vagabonds Ladies to welcome Bury to Ballafletcher
Football: FA Cup & Woods Cup continue on busy weekend schedule
Northern showdown in top flight among league clashes
