South Lancashire and Cheshire Division Two leaders Douglas face a tough test to stay top, away to title and promotion rivals Crewe and Nantwich this afternoon (Saturday).
The sides met two weeks ago at Port-e-Chee when a late try earned the Manx side a 5-5 draw.
Vagabonds are also in action off the Island, at Oldershaw.
Ramsey welcome Ellesmere Port to Mooragh Park having convincingly won away to the same opponents a fortnight ago, and held Douglas to a draw last Saturday.
Vagabonds ladies will be out to gain their first points of the season at Eccles.