Champs host Ramsey
With a big advantage of twelve points at the top of the Canada Life Premier League, St. George's face a Ramsey side fighting to stay up at Glencrutchery Road.
Second placed Peel have four games in hand but can't afford to slip at home to sixth-in-the-table Laxey.
The other sides involved in the battle to avoid the drop all face tough encounters.
Union Mills travel to in-form Corinthians and Marown are at third-placed Rushen.
Old Boys v Ayre and St. Mary's v St. John's were postponed on Friday and pitch inspections at many grounds are expected to take place on Saturday morning.
The last G.H. Corlett Woods Cup quarter-final will be played at Ballafletcher when Douglas Royal host Division Two runaway leaders Douglas Athletic.