Leaders St. George's at Ramsey
The battle for Football's Canada Life Premier League sees the two main contenders playing away games.
Champions and leaders St. George's travel north to Ballacloan Stadium to play struggling Ramsey who currently occupy the second relegation place.
Peel are second in the table on goal difference and face a potentially tricky trip to fourth placed Laxey.
Elsewhere, Rushen can virtually seal qualification for the Railway Cup semi-finals if they come away from Marown with three points.
Ayre welcome Old Boys and Corinthians go to Union Mills.
In Division Two, four of the top six play each other - Colby entertain Braddan and Gymns welcome Pulrose.
Runaway leaders Douglas Athletic meet bottom side Governors Athletic looking to make it eleven wins from eleven games.
Third-placed Castletown are at Onchan.