Douglas and Vagabonds kept the Manx flag flying with wins over Moore and Trentham respectively in South Lancashire/Cheshire Division Two.
Ramsey, however, went down away at bottom side Marple.
Douglas stuttered to a bonus point win at Port-e-Chee.
Carl Markle-Fearns and Andy Evans got them off to a flying start.
Mike Hebden added a third try as Douglas held a 19-10 half-time lead.
Moore kicked their way back to level pegging in the second half before a Will Latta try, plus a penalty and drop goal from Bryn Snellgrove, sealed the win.
Vagas got their first league win at Ballafletcher in impressive style, blowing away Trentham 56-5.
Tom Gascoyne was the star with four tries.
Ross McCulloch bagged a hat trick and there were also tries from Akkie van der Berg, Leigh Kennaugh and Andy Pease.
Ramsey plunged into relegation danger when they were beaten 29-18 by bottom side Moore.
Lance Wyllie and Adam Yates both picked up tries for Ramsey.
There was also a conversion and two penalties from Fintan Cummins.
Marple are replaced at the foot of the table by Trentham with Ramsey occupying the second relegation spot.