Medics at Ballafletcher
Rugby - Cheshire South leaders Manchester Medics make the trip to the Island on Saturday to face Vagabonds at Ballafletcher.
Vagas need to get something from the match after defeat away to Oswestry last weekend put a dent in their promotion push.
Ramsey entertain Marple at Mooragh Park.
In South Lancashire & Cheshire Division One, Douglas play Liverpool Collegiate at Port-e-Chee.
It should be an interesting clash as both sides have little to worry about in the league table.
And Vagabonds ladies are away - they make the long trip to the east coast of England to face Hull.
FC Isle of Man to start another hectic week at Charnock Richard
Success for Manx riders at Bob Smith Spring Cup
Football: Prem & Div 2 action kicks off busy midweek schedule
Boxing: Gold for Phair in Sweden
McGuinness 'in a really sweet spot' heading into TT
Football: Peel crowned women's league champions
