Westerners go to Blackberry Lane
The top two matches in the Canada Life Premier League take place within a mile of each other in North Douglas.
At Blackberry Lane, leaders Peel go to Old Boys while at Glencrutchery Road Champions St. George's host St. Mary's.
Elsewhere in the top flight, Corinthians head south to tackle Rushen, Marown and Ramsey Youth Centre meet in a game that could have a major say in the battle to avoid relegation, Ramsey entertain bottom-side Union Mills and St. John's travel to Ayre.
Division Two leaders Douglas Athletic are at home to Onchan while second placed Braddan face Pulrose.