Football - the top two in the Canada Life Premier League clash at Glen Road on Saturday afternoon.
Leaders Laxey face champions St. George's in the match of the day.
Third-placed Peel are at home to St. John's in the western derby.
In Rugby's South Lancashire and Cheshire Division Two, unbeaten Douglas and Vagabonds look to maintain their 100% records.
Douglas entertain Marple at Port-e-Chee while Vagabonds travel away again, this time to Southport.
Ramsey are also on the road at Sefton.
And in Hockey, Champions Valkyrs "A" play Celts - both sides won their opening games of the season last Saturday.
Leaders Bacchas "A" meet their own "B" team in a club derby.
Rugby: Manx club's passionate plea for new players
Football: Castletown beat southern rivals to go top of Division 2
Rugby: Douglas continue strong run at Birkenhead Park
Hockey: Valkyrs B move to the top of Mixed Division One
